New Survey Finds Rheumatoid Arthritis Patients Value Personalised Goal Setting For Successful Disease Management

UCB today announced data that showed patients with rheumatoid arthritis (RA) believe that personalised goal setting can have a positive impact on their disease management. However, while the majority of patients surveyed (87%) agreed with this, almost as many (73%) stated that their healthcare professional (HCP) did not discuss approaches that achieved personal targets.1 The results from the 'Getting to Your Destination Faster' Survey were presented during the Annual Meeting of the European League Against Rheumatism (EULAR) in London, May 25-28.1

Should Orthopaedic Surgeons Recommend Weight Loss To Patients Prior To Joint Replacement?

The obesity epidemic in America and its impact on musculoskeletal health, as well as related treatment outcomes and costs, was discussed during the AAOS Now forum, "Obesity, Orthopaedics and Outcomes," at the 2013 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS) at McCormick Place in Chicago.

Medications Used To Treat Rheumatoid Arthritis May Affect Abortion Rate In Women

A new study published in the American College of Rheumatology (ACR) journal, Arthritis Care & Research, reveals that women with rheumatoid arthritis (RA) who were on methotrexate (MTX), a drug commonly used to reduce inflammation caused by RA, had lower rates of induced abortions compared to women with RA who were not exposed to the medication. Findings indicate that women with RA exposed to anti-tumor necrosis factor (anti-TNF) drugs may have increased abortion rates compared to unexposed women.

Risk For Rheumatoid Arthritis Increased By Smoking

A researcher at The Feinstein Institute for Medical Research has discovered additional mechanical properties of articular cartilage, a protective cartilage on the ends of bones that wears down over time, resulting in the development of osteoarthritis. The findings are published in the April issue of PLOS ONE.

Cancer Cells' Achilles' Heel Revealed

Scientists from the Manchester Collaborative Centre for Inflammation Research (MCCIR) have discovered why a particular cancer drug is so effective at killing cells. Their findings could be used to aid the design of future cancer treatments.

Professor Daniel Davis and his team used high quality video imaging to investigate why the drug rituximab is so effective at killing cancerous B cells. It is widely used in the treatment of B cell malignancies, such as lymphoma and leukaemia - as well as in autoimmune diseases like rheumatoid arthritis.

Hydrogen Sulfide Reduces Joint Swelling

A gas associated with the smell of rotten eggs has proven to effectively reduce joint swelling, in research which could lead to advances in the treatment of arthritis.

Scientists at the University of Exeter Medical School have discovered that a novel drug molecule, which slowly generates the gas hydrogen sulfide (H2S), effectively reduces swelling and inflammation in arthritic joints.

For years, H2S has been regarded as a highly poisonous by-product which is corrosive, flammable and explosive. But research is now showing an altogether more benign side to the substance.

Natural Fibres Biologically Effective For Use In Stem Cell Cartilage Repair

Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer.

Researchers Able To Prevent And Cure Type 1 Diabetes In Animal Models

Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed.

The discovery has wider repercussions, as the protein is responsible for protecting the body against excessive immune responses, and could be used to treat, or even prevent, other immune disorders such as multiple sclerosis and rheumatoid arthritis.

News From The Annals Of Family Medicine, May/June 2013

Much of the May/June 2013 issue of Annals of Family Medicine and the entirety of an accompanying supplement published in partnership with the U.S. Agency for Healthcare Research and Quality are about changing primary care practice. Practice transformation on a large scale toward the patient-centered medical home model of care is a cornerstone of health care reform efforts in the United States, and the research and commentary in this issue can serve as a roadmap to achieve practice transformation.

Grapefruit-Derived Nanovectors Provide A Secret Weapon In Medical Drug Delivery

University of Louisville researchers have uncovered how to create nanoparticles using natural lipids derived from grapefruit, and have discovered how to use them as drug delivery vehicles. UofL scientists Huang-Ge Zhang, D.V.M., Ph.D., Qilong Wang, Ph.D., and their team have published their findings in Nature Communications.

Lipids derived from grapefruit. GNVs can efficiently deliver a variety of therapeutic agents, including DNA, RNA (DIR-GNVs), proteins and anti-cancer drugs (GNVs-Drugs) as demonstrated in this study.